Preparation and characterization of novel poly(ε-caprolactone)/biphasic calcium phosphate hybrid composite microspheres.

@article{Bao2011PreparationAC,
  title={Preparation and characterization of novel poly(ε-caprolactone)/biphasic calcium phosphate hybrid composite microspheres.},
  author={Trinh-Quang Bao and Rose-Ann Franco and Byong Taek Lee},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2011},
  volume={98 2},
  pages={272-9}
}
Desirably porous biodegradable hybrid composite microspheres were fabricated for use in bone graft and bone substitute applications. In this study, novel poly(ε-caprolactone)/biphasic calcium phosphate (70/30) composite microspheres (PCL/BCP MPs) were prepared using the emulsion solvent-evaporation method. Throughout this process, the ammonium bicarbonate (NH₄HCO₃) content was changed to obtain the desired porous structure. However, to maintain the spherical shape, the NH₄HCO₃ content should… CONTINUE READING