Preparation and characterization of new WHO reference reagents for human chorionic gonadotropin and metabolites.

@article{Birken2003PreparationAC,
  title={Preparation and characterization of new WHO reference reagents for human chorionic gonadotropin and metabolites.},
  author={Steven Birken and Peter Berger and J M Bidart and M Weber and Adrian F. Bristow and Rob Norman and Catharine M. Sturgeon and U Stenman},
  journal={Clinical chemistry},
  year={2003},
  volume={49 1},
  pages={144-54}
}
BACKGROUND The currently used standards for human chorionic gonadotropin (hCG) and its alpha and beta subunits (hCGalpha and hCGbeta) contain substantial amounts of contaminating variants of hCG and other impurities. Furthermore, some partially degraded forms of hCG and its subunits have become of potential clinical importance, e.g., "nicked" forms of hCG (hCGn) and hCGbeta (hCGbetan), which contain cuts in the peptide backbone between amino acids 44-45 or 47-48 in hCGbeta, and a fragment of… CONTINUE READING

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