Preparation and characterization of intravenously injectable nimodipine nanosuspension.

  title={Preparation and characterization of intravenously injectable nimodipine nanosuspension.},
  author={Ruolan Xiong and Weigen Lu and Jun Li and Peiquan Wang and Rong Xu and Ting-Ting Chen},
  journal={International journal of pharmaceutics},
  volume={350 1-2},
The purpose of this study was to develop an alternative, improved and better tolerated injectable nimodipine nanosuspension compared with commercially available ethanol solution. In this study, nimodipine nanosuspension was prepared by high-pressure homogenization (HPH). The effects of the production parameters such as pressure, cycle numbers and crushing principles on the mean particle size, 99% diameter and polydispersity of the nanosuspension were investigated. Characterization of the… CONTINUE READING