Preparation and characterization of inclusion complexes of a cationic beta-cyclodextrin polymer with butylparaben or triclosan.

@article{Qian2008PreparationAC,
  title={Preparation and characterization of inclusion complexes of a cationic beta-cyclodextrin polymer with butylparaben or triclosan.},
  author={Liying Qian and Yan Xiang Guan and Haiyan J. Xiao},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={357 1-2},
  pages={
          244-51
        }
}
The preparation of a cationic beta-cyclodextrin polymer (CPbetaCD) and its complexes with butylparaben and triclosan were reported in this paper. FT-IR and 2D 1H-1H gCOSY NMR spectra confirmed that the antibiotics could be included inside of the lipophilic cavities of CPbetaCD. The formation of complexation of CPbetaCD with the antibiotics significantly improved the water solubility. The solubility of the antibiotics linearly increased with the concentration of CPbetaCD, and the values of the… CONTINUE READING

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