Preparation and characterization of hyaluronan oligosaccharides for angiogenesis study.

@article{Gao2006PreparationAC,
  title={Preparation and characterization of hyaluronan oligosaccharides for angiogenesis study.},
  author={Feng Guang Gao and Manlin Cao and Cuixia Yang and Yiqing He and Yiwen Liu},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2006},
  volume={78 2},
  pages={385-92}
}
Low molecular weight hyaluronan (HA) is proved to be active in stimulating endothelial cell (EC) proliferation. The study is to obtain biological active HA fragments of defined length from high molecular weight HA for angiogenesis research. A novel method, by a high-voltage polyacrylamide-gel electrophoresis (PAGE) that uses specific fluorophore labeling, was developed to identify the degraded products digested from native high molecular weight HA. The polymer HA was digested by hyaluornidase… CONTINUE READING

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