Preparation and characterization of flurbiprofen beads by melt solidification technique

  title={Preparation and characterization of flurbiprofen beads by melt solidification technique},
  author={A. Paradkar and M. Maheshwari and A. Tyagi and B. Chauhan and S. Kadam},
  journal={AAPS PharmSciTech},
  • A. Paradkar, M. Maheshwari, +2 authors S. Kadam
  • Published 2008
  • Materials Science, Medicine
  • AAPS PharmSciTech
  • Amelt solidification technique has been developed to obtain sustained-release waxy beads of flurbiprofen. Low glass transition temperature (tg) and shear-induced crystallization of flurbiprofen made it a suitable candidate for melt solidification technique. The process involved emulsification and solidification of flurbiprofen-cetyl alcohol melt at significantly low temperature (5°C). The effect of variables, namely, the amount of cetyl alcohol and the speed of agitation, was studied using 32… CONTINUE READING
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