Preparation and characterization of flurbiprofen beads by melt solidification technique

@article{Paradkar2008PreparationAC,
  title={Preparation and characterization of flurbiprofen beads by melt solidification technique},
  author={A. Paradkar and M. Maheshwari and A. Tyagi and B. Chauhan and S. Kadam},
  journal={AAPS PharmSciTech},
  year={2008},
  volume={4},
  pages={514-522}
}
  • A. Paradkar, M. Maheshwari, +2 authors S. Kadam
  • Published 2008
  • Materials Science, Medicine
  • AAPS PharmSciTech
    • Amelt solidification technique has been developed to obtain sustained-release waxy beads of flurbiprofen. Low glass transition temperature (tg) and shear-induced crystallization of flurbiprofen made it a suitable candidate for melt solidification technique. The process involved emulsification and solidification of flurbiprofen-cetyl alcohol melt at significantly low temperature (5°C). The effect of variables, namely, the amount of cetyl alcohol and the speed of agitation, was studied using 32… CONTINUE READING
    View on Springer
    europepmc.org
    29 Citations
    Highly Influential Citations
    1
    Background Citations
    5
    Methods Citations
    2
    Results Citations
    2
    29 Citations
    Citation Type

    Citation Type

    Improvement of physicochemical and biopharmaceutical properties of flurbiprofen using melt sonocrystallization technique
    • 12
    Melt solidification technique: Incorporation of higher wax content in ibuprofen beads
    • 34
    FORMULATION AND CHARACTERIZATION OF GELUCIRE PELLETS FOR SUSTAINED RELEASE OF IBUPROFEN
    • 6
    • PDF
    Characterization of Ethylcellulose and Hydroxypropyl MethylcelluloseMicrospheres for Controlled Release of Flurbiprofen
    • 30
    IBUPROFEN­GLYCERYL MONOSTEARATE (GMS) BEADS USING MELT SOLIDIFICATION TECHNIQUE: EFFECT OF HLB
    • 4
    Controlled precipitation for enhanced dissolution rate of flurbiprofen: development of rapidly disintegrating tablets
    • 8
    Devlopment and Evaluation of Ketoprofen Loaded lipid Microspheres for controlled release Drug Delivery
    • PDF
    Encapsulation and characterization of flurbiprofen loaded poly(є-caprolactone)–poly(vinylpyrrolidone) blend micropheres by solvent evaporation method
    • 29
    Crystal engineering of bioactive plumbagin using anti-solvent precipitation, melt solidification and sonocrystallization techniques
    • 8
    Agglomeration of ibuprofen with talc by novel crystallo-co-agglomeration technique
    • 52

    References

    SHOWING 1-10 OF 15 REFERENCES
    Preparation and characterization of ibuprofen-cetyl alcohol beads by melt solidification technique: effect of variables.
    • 48
    Preparation and characterisation of ibuprofen-poloxamer 188 granules obtained by melt granulation.
    • 196
    Compritol 888 ATO: an innovative hot-melt coating agent for prolonged-release drug formulations.
    • P. Barthelemy, J. Laforet, N. Farah, J. Joachim
    • Materials Science, Medicine
    • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
    • 1999
    • 98
    Preparation and evaluation of ibuprofen beads by melt solidification technique.
    • 61
    Development and Evaluation of Sustained-Release Ibuprofen-Wax Microspheres. I. Effect of Formulation Variables on Physical Characteristics
    • 52
    Process and formulation variables in the preparation of wax microparticles by a melt dispersion technique. I. Oil-in-water technique for water-insoluble drugs.
    • 45
    Development of Matrix Controlled Release Beads by Extrusion-Spheronization Technology Using a Statistical Screening Design
    • 41
    Melt Granulation in A Laboratory Scale High Shear Mixer
    • 145
    Development and Evaluation of Sustained-Release Ibuprofen–Wax Microspheres. II. In Vitro Dissolution Studies
    • 71
    Prediction of degree of deformation and crystallization time of molten droplets in pastillation process.
    • J. Kim, J. Ulrich
    • Materials Science, Medicine
    • International journal of pharmaceutics
    • 2003
    • 28