Preparation and characterization of coenzyme Q10-Eudragit solid dispersion.

  title={Preparation and characterization of coenzyme Q10-Eudragit solid dispersion.},
  author={Sami Nazzal and Necip Guven and I. Ajit Kumar Reddy and Mansoor A. Khan},
  journal={Drug development and industrial pharmacy},
  volume={28 1},
A solid dispersion of Coenzyme Q10 and Eudragit L 100-55 was prepared using solvent evaporation method. Solid dispersion, physical mixture, and pure compound were then characterized using differential scanning calorimetry and powder x-ray diffraction. Solubility of CoQ10 in different surfactant media was measured, and a suitable dissolution medium was developed to compare the dissolution patterns of the solid dispersion, physical mixture, and the pure compound. Combining labrasol with different… CONTINUE READING