Preparation and characterization of an immunogenic meningococcal group A conjugate vaccine for use in Africa.

@article{Lee2009PreparationAC,
  title={Preparation and characterization of an immunogenic meningococcal group A conjugate vaccine for use in Africa.},
  author={Che-hung Lee and Wen-Chun Kuo and Suresh Beri and Subash Kapre and Jayant S. Joshi and Nancy Bouveret and F Marc Laforce and Carl E. Frasch},
  journal={Vaccine},
  year={2009},
  volume={27 5},
  pages={726-32}
}
Periodic epidemics of group A meningococcal (Mn A) meningitis continue to occur in sub-Saharan Africa. For its prevention, a Mn A polysaccharide (PS)-tetanus toxoid (TT) conjugate vaccine was developed using reductive amination of polysaccharide aldehydes and toxoid hydrazides. In mouse immunization studies, a schedule of three bi-weekly s.c. immunizations of 0.1 or 1mug of the conjugate (PS content) without an adjuvant induced serum antibody levels of >10,000units/mL measured by enzyme-linked… CONTINUE READING
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