Preparation and characterization of a highly macroporous biodegradable composite tissue engineering scaffold.

@article{Guan2004PreparationAC,
  title={Preparation and characterization of a highly macroporous biodegradable composite tissue engineering scaffold.},
  author={Limin Guan and John E. Davies},
  journal={Journal of biomedical materials research. Part A},
  year={2004},
  volume={71 3},
  pages={480-7}
}
A unique composite scaffold for bone-tissue engineering applications has been prepared by combining biodegradable poly(lactide-co-glycolide) (PLGA) with bioresorbable calcium phosphate (CaP) cement particles through the process of particle fusion and phase separation/particle leaching. The scaffold is characterized by a highly interconnected macroporosity, with macropores of 0.8-1.8 mm and porosities ranging from 81% to 91%, and improved mechanical properties with respect to the polymer alone… CONTINUE READING