Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes.

@article{Balthasar2005PreparationAC,
  title={Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes.},
  author={Sabine Balthasar and Kerstin Michaelis and Norbert Dinauer and Hagen von Briesen and Joerg Kreuter and Klaus Langer},
  journal={Biomaterials},
  year={2005},
  volume={26 15},
  pages={2723-32}
}
Established methods of protein chemistry can be used for the effective attachment of drug targeting ligands to the surface of protein-based nanoparticles. In the present work gelatin nanoparticles were used for the attachment of biotinylated anti-CD3 antibodies by avidin-biotin-complex formation. These antibody modified nanoparticles represent a promising carrier system for the specific drug targeting to T-lymphocytes. The objective of this work was the comprehensive quantification of every… CONTINUE READING