Preparation and biodistribution of a (99m)Tc tricarbonyl complex with deoxyglucose dithiocarbamate as a tumor imaging agent for SPECT.
@article{Lin2014PreparationAB, title={Preparation and biodistribution of a (99m)Tc tricarbonyl complex with deoxyglucose dithiocarbamate as a tumor imaging agent for SPECT.}, author={Xiao Lin and Xiaoyu Chao and Junbo Zhang and Zhong-hui Jin and Yan-yan Zhang}, journal={Bioorganic \& medicinal chemistry letters}, year={2014}, volume={24 16}, pages={ 3964-7 } }
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References
SHOWING 1-10 OF 15 REFERENCES
Synthesis and biological evaluation of a novel (99m)Tc nitrido radiopharmaceutical with deoxyglucose dithiocarbamate, showing tumor uptake.
- Chemistry, BiologyBioorganic & medicinal chemistry letters
- 2009
Synthesis and Biodistribution of a New 99mTc‐oxo Complex with Deoxyglucose Dithiocarbamate for Tumor Imaging
- Chemistry, BiologyChemical biology & drug design
- 2012
Single photon emission computed tomography (SPECT) image studies showed there was a visible accumulation in tumor sites, suggesting 99mTcO‐DGDTC would be a promising candidate for tumor imaging.
Synthesis and evaluation of a technetium-99m-labeled diethylenetriaminepentaacetate-deoxyglucose complex ([99mTc]-DTPA-DG) as a potential imaging modality for tumors.
- Chemistry, BiologyApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
- 2006
Biological evaluation of glucose and deoxyglucose derivatives radiolabeled with [99mTc(CO)3(H2O)3]+ core as potential melanoma imaging agents.
- Chemistry, BiologyBioorganic & medicinal chemistry letters
- 2011
Evaluation of 99mTc-glucarate as a breast cancer imaging agent in a xenograft animal model.
- Medicine, BiologyNuclear medicine and biology
- 2011
Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor.
- ChemistryBioorganic & medicinal chemistry letters
- 2006
Radiation dosimetry and biodistribution of 99mTc-ethylene dicysteine-deoxyglucose in patients with non-small-cell lung cancer
- Medicine, ChemistryEuropean Journal of Nuclear Medicine and Molecular Imaging
- 2009
99mTc-EC-DG has acceptable dosimetric and biodistribution properties as a diagnostic tumor-imaging agent and future studies are planned to evaluate its diagnostic potential.
Synthesis and biodistribution studies of carbohydrate derivatives radiolabeled with technetium-99m.
- Biology, ChemistryBioorganic & medicinal chemistry letters
- 2010
A novel D-glucose derivative radiolabeled with technetium-99m: synthesis, biodistribution studies and scintigraphic images in an experimental model of Ehrlich tumor.
- Biology, ChemistryBioorganic & medicinal chemistry letters
- 2010