Preparation and binding of radioactively labeled porcine transforming growth factor type beta.

@article{Ruff1986PreparationAB,
  title={Preparation and binding of radioactively labeled porcine transforming growth factor type beta.},
  author={Eric Ruff and Angie Rizzino},
  journal={Biochemical and biophysical research communications},
  year={1986},
  volume={138 2},
  pages={714-9}
}
This report describes the labeling of porcine transforming growth factor type beta (TGF-beta) with 125-iodine. Its binding to NRK cells and three other cell lines has been examined. The data indicate that NRK cells exhibit approximately 10,000 receptors for porcine TGF-beta per cell, with an apparent dissociation constant of 45 pM. The binding of porcine 125I-TGF-beta can be blocked by porcine, murine and human TGF-beta but not by several well characterized growth factors. In all respects… CONTINUE READING

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