Preparation and antitrypanosomal activity of secochiliolide acid derivatives.

  title={Preparation and antitrypanosomal activity of secochiliolide acid derivatives.},
  author={Gast{\'o}n E. Siless and Esteban Sebasti{\'a}n Lozano and Marianela S{\'a}nchez and Marcia Mazzuca and Miguel A Sosa and Jorge A. Palermo},
  journal={Bioorganic \& medicinal chemistry letters},
  volume={23 17},
Secochiliolide acid (1) isolated from the Patagonian shrub Nardophyllum bryoides, was used as a scaffold for the preparation of a series of nine derivatives. Compound 1 and its derivatives were tested against Trypanosoma cruzi epimastigotes grown in liquid media. It was first observed that secochiliolide acid (1) inhibited the proliferation of the parasites, with an IC50 of 2 μg/mL. Six of the synthesized derivatives were also active with IC50's between 2 and 7 μg/mL which are comparable to… 
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  • V. Duschak
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