Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs.

@article{Lee2005PreparationAA,
  title={Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs.},
  author={Su-Lin Lee and Wei-jan Huang and Wan Wan Lin and S S Lee and Chung-Hsiung Chen},
  journal={Bioorganic & medicinal chemistry},
  year={2005},
  volume={13 22},
  pages={6175-81}
}
Seven diarylheptylamine (12a-g) and four diarylheptanoid analogs (3-5, 9), structurally related to the natural anti-inflammatory agent oregonin (1), have been prepared from curcumin (2) for evaluation of their activity against the expression of iNOS and COX-2. Diarylheptylamine 12b and diarylheptanoid analogs can inhibit iNOS and COX-2 responses of LPS, although less potently than 1. These compounds, however, possess stronger potency than 1 against COX-2-derived PGE2 formation, of which… CONTINUE READING

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