Preparation and analysis of oligonucleotides containing the c4'-oxidized abasic site and related mechanistic probes.

@article{Kim2005PreparationAA,
  title={Preparation and analysis of oligonucleotides containing the c4'-oxidized abasic site and related mechanistic probes.},
  author={Jaeseung Kim and Cortney R Kreller and Marc M Greenberg},
  journal={The Journal of organic chemistry},
  year={2005},
  volume={70 20},
  pages={8122-9}
}
The C4'-oxidized abasic site (C4-AP) is produced by a variety of DNA damaging agents. This alkali labile lesion can exist in up to four diastereomeric cyclic forms, in addition to the acyclic keto-aldehyde. Synthetic oligonucleotides containing the lesion were prepared from a stable photochemical precursor. Chemical integrity of the lesion containing… CONTINUE READING