Preparation and Therapeutic Efficacy of Polysorbate-80-Coated Amphotericin B/PLA-b-PEG Nanoparticles

  title={Preparation and Therapeutic Efficacy of Polysorbate-80-Coated Amphotericin B/PLA-b-PEG Nanoparticles},
  author={Tianbin Ren and Nan Xu and Chunhong Cao and Weizhong Yuan and Xiao Yu and Jiang-han Chen and Jie Ren},
  journal={Journal of Biomaterials Science, Polymer Edition},
  pages={1369 - 1380}
  • T. RenN. Xu Jie Ren
  • Published 1 January 2009
  • Chemistry, Biology
  • Journal of Biomaterials Science, Polymer Edition
Amphotericin B (AmB)/poly(lactic acid)-b-poly(ethylene glycol) (PLA-b-PEG) nanoparticles coated with polysorbate 80 (Tween-80) were prepared by nanoprecipitation for transport across the blood–brain barrier (BBB). The effects of Tween-80 on the size and distribution, entrapment efficiency and release behavior of AmB/PLA-b-PEG nanoparticles were investigated. Furthermore, the brain targeting and curative effect of coated nanoparticles were also investigated. The entrapment efficiency was… 

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