• Corpus ID: 189807870

Preparation and Physicochemical Evaluation of Oral Disintegrated Tablet Containing Dicyclomine Hydrochloride

@inproceedings{Taymouri2018PreparationAP,
  title={Preparation and Physicochemical Evaluation of Oral Disintegrated Tablet Containing Dicyclomine Hydrochloride},
  author={Somayeh Taymouri and Sayed Abolfazl Mostafavi and Sadegh Yazdankhah},
  year={2018}
}

• Somayeh Taymouri, S. Mostafavi, Sadegh Yazdankhah
• Published 2018
• Materials Science

Dicyclomine hydrochloride is anticholinergic used as an anti-spasmodic drug. The aim of this study was to prepare hard and fast oral disintegrating tablets (ODTs) containing Dicyclomine hydrochloride which can release drug at the least possible time. The ODTs serve as an alternative dosage form for patients who experience dysphagia (difficulty in swallowing) or for increasing the patient compliance. The ODTs were prepared using croscarmellose, crospovidone, and mallow mucilage as superdisintegrants. Tablets formulated by direct compression method and various parameters were evaluated. Based on disintegration time and hardness of tablets, two types of superdisintegrants (mallow mucilage and croscarmelose) selected and different ODTs containing combination of two superdisintegrant were prepared. Angle of repose and Carr’s index of tested powders were in the range of 27.3 to 30.1 and 9.3 to 23.91 respectively. These findings indicated that the powder prepared possessed appropriate flow properties. The ODTs of dicyclomine showed uniform content and low weight variation. Friability percent was below 0.8%, which was in acceptable limit. The tablet formulations contained mucilage at concentrations of 3.3-5% in combination with croscarmelose showed lower disintegration time as compared to those containing mucilage alone. Formulation containing 5% mucilage and 3.3% croscarmelose identified as optimum formulation because of lowest disintegration time, acceptable drug release time and appropriate hardness. *Corresponding Author: Sayed Abolfazl Mostafavi, E-mail: [e-mail] Copyright © 2018 by Kermanshah University of Medical Sciences Journal of Reports in Pharm c utical Sciences 2018, 7(2), 164-173