Preparation and Evaluation of Curcumin Invasomes
@article{Lakshmi2014PreparationAE, title={Preparation and Evaluation of Curcumin Invasomes}, author={Palghat Krishnamani Lakshmi and V Mounica and Kumar Manoj and Doppalapudi Prasanthi}, journal={International Journal of Drug Delivery}, year={2014}, volume={6}, pages={113-120} }
Curcumin has poor aqueous solubility and has bioavailability problems. Hence in the present study the solubility of curcumin was increased by complexing with cyclodextrin (CD) and Hydroxy propyl β cyclodextrin(HPβCD). This complex was incorporated in to invasomes and then into HPMC gel to prepare as a transdermal formulation. Curcumin cyclodextrin complexes were prepared by physical mixture and co-precipitation method. Different formulations of invasomes containing 0.5, 1.0, 1.5 % of limonene…
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13 Citations
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