Corpus ID: 97640902

Preparation and Evaluation of Curcumin Invasomes

@article{Lakshmi2014PreparationAE,
  title={Preparation and Evaluation of Curcumin Invasomes},
  author={Palghat Krishnamani Lakshmi and V Mounica and Kumar Manoj and Doppalapudi Prasanthi},
  journal={International Journal of Drug Delivery},
  year={2014},
  volume={6},
  pages={113-120}
}
Curcumin has poor aqueous solubility and has bioavailability problems. Hence in the present study the solubility of curcumin was increased by complexing with cyclodextrin (CD) and Hydroxy propyl β cyclodextrin(HPβCD). This complex was incorporated in to invasomes and then into HPMC gel to prepare as a transdermal formulation. Curcumin cyclodextrin complexes were prepared by physical mixture and co-precipitation method. Different formulations of invasomes containing 0.5, 1.0, 1.5 % of limonene… Expand
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Methods Citations
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Dapsone-Loaded Invasomes as a Potential Treatment of Acne: Preparation, Characterization, and In Vivo Skin Deposition Assay
TLDR
Results reveal that the skin retention of DPS can be enhanced usingInvasomes, a unique sulfone with antibiotic and anti-inflammatory activity that has a great potential to treat acne. Expand
Design of long acting invasomal nanovesicles for improved transdermal permeation and bioavailability of asenapine maleate for the chronic treatment of schizophrenia.
TLDR
Ex- vivo skin permeation and in- vivo pharmacokinetic study revealed that transdermal invasomes achieved 2 folds higher Cmax compared to oral suspension and delayed the Tmax from 1.5h to around 4h which permits reduction of dosing frequency to increase patient adherence to medication. Expand
Overall Review on Invasomes
Controlled drug delivery system has been designed to obtain an optimal drug action and targeting the drug to the particular sites in order to reduce the side effect and improve therapeutic efficacy… Expand
Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review
TLDR
The key goal of an invasome-based delivery system is not only to strengthen the efficacy and safety of the drug but also to dramatically increase patient conformity and the therapeutic value to a significant extent. Expand
Bilosomes as a novel carrier for the cutaneous delivery for dapsone as a potential treatment of acne: preparation, characterization and in vivo skin deposition assay
TLDR
Results showed that the amounts of DPS retained in the skin treated with DPS-loaded bilosomes, and DPS alcoholic solution after 24 h were found to be 170.57 ± 55.7 µg/mL, which can be considered a good addition in the field of pharmaceutical drug delivery for effective topical therapy of acne. Expand
Low-Frequency versus High-Frequency Ultrasound-Mediated Transdermal Delivery of Agomelatine-Loaded Invasomes: Development, Optimization and in-vivo Pharmacokinetic Assessment
TLDR
I2-LFU-C4 is a promising transdermal system for AGM and the superiority of I2 invasomes was statistically revealed with respect to EE% (78.6%), PS (313 nm), ZP (−64 mV), Q0.5h (30.1%), Q8h (92%), flux (10.79 µg/cm2/h) and enhancement ratio (4.83). Expand
Invasomes: Potential vesicular systems for transdermal delivery of drug molecules
TLDR
Although invasomes possess potential advantages for transdermal drug delivery, however the stability of invasome limits its value, the present write up describes numerous aspects ofInvasomes including structural features, composition and skin penetration mechanism. Expand
Cytotoxic effect of transdermal invasomal anastrozole gel on MCF-7 breast cancer cell line
Introduction: Anastrozole is an anti-cancer drug, an effective aromatase inhibitor for the treatment of breast cancer in post-menopausal women. As it undergoes extensive first-pass metabolism and has… Expand
Curcumin Innovative Delivery Forms: Paving the ‘Yellow Brick Road’ of Antitumoral Phytotherapy
This review deals with the various aspects involved in the medicinal action of curcumin, from the photosensitivity and its relevance to storage and shelf-life, to the different routes of… Expand
Invasome: A Novel Nanocarrier for Transdermal Drug Delivery
TLDR
Overall, this review suggests that enhanced transdermal penetration of drugs using invasomes provides an appropriate opportunity for the development of lipid vesicular carriers. Expand
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