• Corpus ID: 97640902

Preparation and Evaluation of Curcumin Invasomes

@article{Lakshmi2014PreparationAE,
  title={Preparation and Evaluation of Curcumin Invasomes},
  author={Palghat Krishnamani Lakshmi and V Mounica and Kumar Manoj and Doppalapudi Prasanthi},
  journal={International Journal of Drug Delivery},
  year={2014},
  volume={6},
  pages={113-120}
}
Curcumin has poor aqueous solubility and has bioavailability problems. Hence in the present study the solubility of curcumin was increased by complexing with cyclodextrin (CD) and Hydroxy propyl β cyclodextrin(HPβCD). This complex was incorporated in to invasomes and then into HPMC gel to prepare as a transdermal formulation. Curcumin cyclodextrin complexes were prepared by physical mixture and co-precipitation method. Different formulations of invasomes containing 0.5, 1.0, 1.5 % of limonene… 

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