Preparation and Characterization of a Lovastatin-Loaded Protein-Free Nanostructured Lipid Carrier Resembling High-Density Lipoprotein and Evaluation of its Targeting to Foam Cells

Abstract

This study was designed to investigate whether a non-protein nanostructured lipid carrier (NLC) resembling high-density lipoprotein (HDL) could deliver a hydrophobic anti-atherogenic drug, lovastatin, to foam cells. Lovastatin-loaded NLC (LT-NLC) was prepared by a nanoprecipitation/solvent diffusion method. The LT-NLC-apoprotein (LT-NLC-apo) was prepared by… (More)
DOI: 10.1208/s12249-011-9668-0

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@inproceedings{Gu2011PreparationAC, title={Preparation and Characterization of a Lovastatin-Loaded Protein-Free Nanostructured Lipid Carrier Resembling High-Density Lipoprotein and Evaluation of its Targeting to Foam Cells}, author={Xiao Gu and Wenli Zhang and Jianping Liu and John P. Shaw and Yuanjun Shen and Yiming Xu and Hui Lu and Zimei Wu}, booktitle={AAPS PharmSciTech}, year={2011} }