Preparation and Characterization of Nicotine / Ca-alginate Composite Microcapsules for the Enteric Controlled Drug Release

Abstract

The aim of the present study was to develop drug-loaded microcapsules to increase drug bioavailability at target site especially for colon-targeted oral delivery. Nicotine was selected as a model lipophilic drug. Additives such as gelatin, glycerin and PEG 6000 were added into Ca-alginate composite to prepare microcapsules by using a modification of the… (More)

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