Preparation and Characterization of Methylene Blue-Incorporated Folate-Functionalized Fe3O4/Mesoporous Silica Core/Shell Magnetic Nanoparticles.

@article{Zhao2015PreparationAC,
  title={Preparation and Characterization of Methylene Blue-Incorporated Folate-Functionalized Fe3O4/Mesoporous Silica Core/Shell Magnetic Nanoparticles.},
  author={Xueiing Zhao and Hongli Zhao and Zongyan Chen and Denghao Zhang and Minbo Lan},
  journal={Journal of nanoscience and nanotechnology},
  year={2015},
  volume={15 7},
  pages={4976-83}
}
In the present work, a multifunctional nanomaterial, methylene blue-incorporated folate-functionalized Fe3O4/mesoporous silica core/shell magnetic nanoparticles, has been developed. Firstly, highly biocompatible monodisperse superparamagnetic Fe3O4@mSiO2 core/shell nanoparticles with mesoporous silica shells were synthesized. Then these particles were coated with the covalently bonded biocompatible polymer poly(ethylene glycol) (PEG) and modified with the cancer targeting ligand folic acid (FA… CONTINUE READING