Preparation and Characterization of Low Molecular Weight Heparin by Liquid Phase Plasma Method.

Abstract

An liquid phase plasma process system was applied to the production of low molecular weight heparin. The molecular weight of produed heparin decreased with increasing liquid phase plasma treatment time. The abscission of the chemical bonds between the constituents of heparin by liquid phase plasma reaction did not alter the characteristics of heparin. Formation of any by-products due to side reaction was not observed. It is suggested that heparin was depolymerized by active oxygen radicals produced during the liquid phase plasma reaction.

Cite this paper

@article{Lee2015PreparationAC, title={Preparation and Characterization of Low Molecular Weight Heparin by Liquid Phase Plasma Method.}, author={Do-Jin Lee and Hangun Kim and Byung Hoon Kim and Young-kwon Park and Heon Sang Lee and Sung Hoon Park and Sang-Chul Jung}, journal={Journal of nanoscience and nanotechnology}, year={2015}, volume={15 8}, pages={6210-3} }