Preparation and Characterization of Dictyophora indusiata Polysaccharide-Zinc Complex and Its Augmented Antiproliferative Activity on Human Cancer Cells.

@article{Liao2015PreparationAC,
  title={Preparation and Characterization of Dictyophora indusiata Polysaccharide-Zinc Complex and Its Augmented Antiproliferative Activity on Human Cancer Cells.},
  author={Wenzhen Liao and Yunjun Lu and Junning Fu and Zheng-xiang Ning and Jiguo Yang and Jiaoyan Ren},
  journal={Journal of agricultural and food chemistry},
  year={2015},
  volume={63 29},
  pages={
          6525-34
        }
}
Dictyophora indusiata polysaccharide (DP1) was successfully chelated with zinc chloride to achieve its enhanced antiproliferative activity. The obtained DP1-Zn complex showed significant antiproliferative activity (18.1 ± 2.84% viability of MCF-7 cells at 250 μg/mL) on a group of human cancer cell lines through induction of apoptosis. The pro-apoptotic action of DP1-Zn was confirmed by morphological changes including chromatin condensation, DNA breakage, and S phase cell cycle arrest in human… Expand
Cell-based evaluation of a novel Dictyophora indusiata polysaccharide against oxidative-induced erythrocyte hemolysis.
TLDR
The possible intracellular antioxidant detoxifying mechanism of DP1 was probably via preserving the activities of the antioxidant enzymes as well as inhibiting lipid peroxidation, and thus alleviated erythrocytes oxidation and plasma oxidation. Expand
Preparation of Prunella vulgaris polysaccharide-zinc complex and its antiproliferative activity in HepG2 cells.
TLDR
Results showed that P1-Zn could effectively inhibit the proliferation of HepG2 cells through induction of apoptosis, evidenced by morphological changes, chromatin condensation and G0/G1 phase cell cycle arrest. Expand
Anticancer potential of an exopolysaccharide from Lactobacillus helveticus MB2-1 on human colon cancer HT-29 cells via apoptosis induction.
TLDR
Findings suggest that LHEPS-1 may be developed as an effective food and/or drug for the prevention and therapeutics of cancer, especially human colon cancer. Expand
Synthesis and Characterization of a Walnut Peptides-Zinc Complex and Its Antiproliferative Activity against Human Breast Carcinoma Cells through the Induction of Apoptosis.
TLDR
This work is the first attempt to elucidate the synergic effect of novel walnut peptides and Zn and with the hope of better understanding the antiproliferative action of bioactive peptide and a zinc complex and support the potential application of WP1-Zn as a functional food ingredient or complementary medicine. Expand
A novel polysaccharide from the Sarcodon aspratus triggers apoptosis in Hela cells via induction of mitochondrial dysfunction
TLDR
It is suggested that the anti-tumor (Hela cells) activity of SAP recommended that S. aspratus could be used as a powerful medicinal mushroom against cancer. Expand
Structural characterization of a novel polysaccharide from Hericium erinaceus and its protective effects against H2O2-induced injury in human gastric epithelium cells
Abstract In this paper, a novel water-soluble polysaccharide (HEPW1) was extracted from Hericium erinaceus, physicochemical characterization showed that HEPW1 with a relative molecular weight ofExpand
Structural characterisation and immunomodulatory effects of polysaccharides isolated from Dendrobium aphyllum
A crude polysaccharide extract of Dendrobium aphyllum (cDAP, yield 38.15 0.20%) was generated. The D. aphyllum polysaccharide (DAP, Mw 471.586 kDa), purified by DEAE-Sepharose and Sephadex-G200 FastExpand
Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells.
The protective effects of kaempferol against reactive oxygen species (ROS)-induced hemolysis and its antiproliferative activity on human cancer cells were evaluated in this study. KaempferolExpand
Tormentic acid in foods exerts anti-proliferation efficacy through inducing apoptosis and cell cycle arrest
TLDR
Tormentic acid exhibited a dose-dependent inhibitory effect on MCF-7 cells, which was caused by apoptosis and G0/G1 phase arrest, and significantly down-regulated the NF-kappa-B cell survival pathway and the expression level of phosphorylated ERK. Expand
Facile total synthesis of lysicamine and the anticancer activities of the RuII, RhIII, MnII and ZnII complexes of lysicamine
TLDR
A facile concise total synthesis of lysicamine from simple raw materials under mild reaction conditions is demonstrated and in vivo study showed that 2 inhibited HepG2 tumor growth at 1/3 maximum tolerated dose (MTD) and had a better safety profile than cisplatin. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Structure characterization of a novel polysaccharide from Dictyophora indusiata and its macrophage immunomodulatory activities.
TLDR
The immunostimulating assay indicated that DP1 could significantly promote macrophage NO, TNF-α, and IL-6 secretion in murine RAW 264.7 cells involving complement receptor 3 (CR3). Expand
Antiproliferative and apoptotic activities of linear furocoumarins from Notopterygium incisum on cancer cell lines.
TLDR
It was found that the presence of a free hydroxy at the lipophilic side chain linked to C-5 of the linear furocoumarins was essential for their in vitro antiproliferative activity. Expand
Zinc(II) complexes with dithiocarbamato derivatives: structural characterisation and biological assays on cancerous cell lines.
TLDR
The results on the synthesis and characterisation of ZnL(2) complexes with five different dithiocarbamato derivatives, such as dimethyl-(DMDT), pyrrolidine-(PyDT), methyl-(MSDT), ethyl-(ESDT) and tert-butyl-(TSDT) sarcosinedithuocarbamate have fully been characterised by means of several spectroscopic techniques. Expand
Immunomodulatory activity of polysaccharide isolated from Angelica sinensis.
TLDR
The time-effect relation of cytokines response also suggests that macrophages and natural killer cells involved in nonspecific immunity were primary activated, and helper T cell were secondarily affected by AP. Expand
Selenium nanoparticles inhibit the growth of HeLa and MDA-MB-231 cells through induction of S phase arrest.
TLDR
The results suggested that nanoSe(0) may be more helpful in cancer chemoprevention as a potential anticancer drug. Expand
Synthesis and characterization of copper(II) and zinc(II)-based potential chemotherapeutic compounds: their biological evaluation viz. DNA binding profile, cleavage and antimicrobial activity.
TLDR
In vitro DNA binding studies of complexes 1 and 2 with CT DNA revealed that complex 1 has better prospectus to act as cancer chemotherapeutic candidate which warrants further in vitro and in vivo anticancer investigations. Expand
Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells.
TLDR
Observations suggest that polyphyllin D is a potent anti-cancer agent that bypasses MDR and elicits apoptosis via mitochondrial injury. Expand
Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generation.
TLDR
Diosmetin could significantly restore AAPH-induced increase of intracelluar antioxidant enzyme (SOD, GPx, and CAT) activities to normal levels, as well as inhibit intracellular malondialdehyde (MDA) formation. Expand
PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction
TLDR
The results suggest that PEG-SeNPs may be a candidate for further evaluation as a chemotherapeutic agent for drug-resistant liver cancer, and the strategy to use PEG200 as a surface decorator could be a highly efficient way to enhance the anticancer efficacy of nanomaterials. Expand
Immunomodulation and anti-cancer activity of polysaccharide-protein complexes.
  • V. Ooi, F. Liu
  • Biology, Medicine
  • Current medicinal chemistry
  • 2000
TLDR
Polysaccharides or polysaccharide-protein complexes are considered as multi-cytokine inducers that are able to induce gene expression of vaious immunomodulatory cytokines and cytokine receptors and act as biological response modifiers. Expand
...
1
2
3
4
...