• DOI:10.1016/bs.mie.2018.01.031
Corpus ID: 49274646

Preparation and Characterization of Tetrabromopyrrole Debrominase From Marine Proteobacteria.

@article{Chekan2018PreparationAC,
  title={Preparation and Characterization of Tetrabromopyrrole Debrominase From Marine Proteobacteria.},
  author={J. R. Chekan and B. Moore},
  journal={Methods in enzymology},
  year={2018},
  volume={605},
  pages={
          253-265
        }
}

J. R. Chekan, B. Moore

Published 2018

Chemistry, Medicine

Methods in enzymology

While halogenases have been studied for decades, the first natural product dehalogenase was only recently described. This bacterial enzyme, Bmp8, catalyzes the reductive debromination of 2,3,4,5-tetrabromopyrrole to form 2,3,4-tribromopyrrole as part of the biosynthesis of pentabromopseudilin, a marine natural product. Bmp8 is hypothesized to utilize a catalytic mechanism analogous to the important human thyroid hormone deiodinase enzyme family, potentially enabling Bmp8 to serve as model… CONTINUE READING

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