Preparation and Characterization of Tetrabromopyrrole Debrominase From Marine Proteobacteria.

@article{Chekan2018PreparationAC,
  title={Preparation and Characterization of Tetrabromopyrrole Debrominase From Marine Proteobacteria.},
  author={J. R. Chekan and B. Moore},
  journal={Methods in enzymology},
  year={2018},
  volume={605},
  pages={
          253-265
        }
}
  • J. R. Chekan, B. Moore
  • Published 2018
  • Chemistry, Medicine
  • Methods in enzymology
  • While halogenases have been studied for decades, the first natural product dehalogenase was only recently described. This bacterial enzyme, Bmp8, catalyzes the reductive debromination of 2,3,4,5-tetrabromopyrrole to form 2,3,4-tribromopyrrole as part of the biosynthesis of pentabromopseudilin, a marine natural product. Bmp8 is hypothesized to utilize a catalytic mechanism analogous to the important human thyroid hormone deiodinase enzyme family, potentially enabling Bmp8 to serve as model… CONTINUE READING
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