Preparation, characterization and pharmacological evaluation of tolterodine hydrogels for the treatment of overactive bladder.

@article{Sun2013PreparationCA,
  title={Preparation, characterization and pharmacological evaluation of tolterodine hydrogels for the treatment of overactive bladder.},
  author={Fengying Sun and Cheng Hua Sui and Yulin Zhou and Ximing Liu and Yanan Shi and Yi Wu and Youxin Li},
  journal={International journal of pharmaceutics},
  year={2013},
  volume={454 1},
  pages={
          532-8
        }
}
In this study, transdermal gel formulations for tolterodine were developed to investigate the effects of gel matrix and chemical enhancers on drug skin permeation from tolterodine hydrogels. In vitro permeation studies of tolterodine through excised mouse skin were carried out using Franz-type diffusion cells. In the optimum gel formulation, Carbopol 940 was selected as the gel matrix. Compared to gels without enhancer, tolterodine hydrogels with N-methyl pyrrolidone (NMP) showed significant… CONTINUE READING
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