Preparation, characterization and in vivo evaluation of formulation of repaglinide with hydroxypropyl-β-cyclodextrin.

@article{Liu2014PreparationCA,
  title={Preparation, characterization and in vivo evaluation of formulation of repaglinide with hydroxypropyl-β-cyclodextrin.},
  author={Meina Liu and Wen Cao and Yinghua Sun and Zhonggui He},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={477 1-2},
  pages={159-66}
}
The therapeutic efficacy of repaglinide (RPG) is limited by the low and variable oral bioavailability owing to its limited aqueous solubility. In our present study, the development and evaluation of inclusion complex applying hydroxypropyl-β-cyclodextrin (HP-β-CD) for the improvement of oral bioavailability of repaglinide was investigated systematically. The inclusion complex of repaglinide was prepared by lyophilization technique using drug: hydroxypropyl-β-cyclodextrin (1:15 mole). The… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Phospholipid complex enriched micelles: A novel drug delivery approach for promoting the antidiabetic effect of repaglinide.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Ionization, lipophilicity and solubility properties of repaglinide.

Journal of pharmaceutical and biomedical analysis • 2006
View 3 Excerpts
Highly Influenced

Influence of method of preparation on inclusion complexes of naproxen with different cyclodextrins

J. Blanco, J. L. Vila-jato, F. Otero, S. Anguiano
Drug Dev. Ind. Pharm • 1991
View 2 Excerpts
Highly Influenced

Preparation and characterization of inclusion complexes of naringenin with b-cyclodextrin or its derivative

Yang, L.-J, +9 authors X.-D
Carbohydr. Polym • 2013
View 2 Excerpts

Alpinetin/hydroxypropyl-b-cyclodextrin host-guest system: preparation, characterization, inclusion mode, solubilization and stability

Ma, S.-X, +7 authors L.-J
J. Pharm. Biomed. Anal • 2012
View 1 Excerpt

Application of a ternary HP-b-CD-complex approach to improve the dissolution performance of a poorly soluble weak acid under biorelevant conditions

T. Zoeller, J. B. Dressman, S. Klein
Int. J. Pharm • 2012
View 1 Excerpt

In vitro and in vivo studies on a novel solid dispersion of repaglinide using polyvinylpyrrolidone as the carrier

L. R. Zawar, S. B. Bari
Drug Dev . Ind . Pharm . • 2011
View 3 Excerpts

Repaglinide-cyclodextrin complexes: preparation: characterization and in vivo evaluation of antihyperglycemic activity

N. S. Desai, D. M. Bramhane, M. S. Nagarsenker
J. Incl. Phenom. Macrocycl. Chem • 2011
View 2 Excerpts

Similar Papers

Loading similar papers…