Preparation, characterization and in vivo evaluation of bergenin-phospholipid complex

@inproceedings{Qin2010PreparationCA,
  title={Preparation, characterization and in vivo evaluation of bergenin-phospholipid complex},
  author={Xuan Qin and Yang Yang and Ting-ting Fan and Tao Gong and Xiao-ning Zhang and Yuan Huang},
  booktitle={Acta Pharmacologica Sinica},
  year={2010}
}
AbstractAim:To prepare a bergenin-phospholipid complex (BPC) to increase oral bioavailability of the drug.Methods:In order to obtain the acceptable BPC, a spherical symmetric design-response surface methodology was used for process optimization. The influence of reaction medium, temperature, drug concentration and drug-to-phospholipid ratio on the combination percentage and content of bergenin in BPC were evaluated. BPC was then characterized by thin-layer chromatography (TLC), high-performance… CONTINUE READING
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