Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles.

@article{Venkateswarlu2004PreparationCA,
  title={Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles.},
  author={Vobalaboina Venkateswarlu and Kopparam Manjunath},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2004},
  volume={95 3},
  pages={627-38}
}
Clozapine, a lipophilic antipsychotic drug, has very poor oral bioavailability (<27%) due to first pass effect. Solid lipid nanoparticle (SLN) delivery systems of clozapine have been developed using various triglycerides (trimyristin, tripalmitin and tristearin), soylecithin 95%, poloxamer 188 and charge modifier stearylamine. Hot homogenization of melted lipids and aqueous phase followed by ultrasonication at temperature above the melting point of lipid was used to prepare SLN dispersions… CONTINUE READING
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