• Corpus ID: 1598448

Preparation, characterization, and pharmacokinetic evaluation of puerarin submicron emulsion.

@article{Yue2008PreparationCA,
  title={Preparation, characterization, and pharmacokinetic evaluation of puerarin submicron emulsion.},
  author={Peng-fei Yue and Hailong Yuan and Ming Yang and Ronghui You and Long-Bo Cong and Junjun Zhu and Qi Wang and Weifeng Zhu and Xiao‐he Xiao},
  journal={PDA journal of pharmaceutical science and technology},
  year={2008},
  volume={62 1},
  pages={
          32-45
        }
}
A novel formulation of puerarin was studied. Puerarin submicron emulsion was prepared by complex phase inversion-high-pressure homogenization technology. Characterization, distribution of drug in emulsion, short-term stability, and pharmacokinetics of emulsion were evaluated. The mean diameter and zeta potential of puerarin emulsion were 188.14 nm and -29.45 mv, respectively. The distribution range of puerarin emulsion was very narrow. The concentration of puerarin in the interfacial surface… 

Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine

TLDR
The pharmacokinetics and drug delivery systems of puerarin up to date are summarized and more effective quality evaluations of nanocarriers are required in order to achieve biocompatibility and desired activity.

Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MS/MS after Oral Administration of Pueraria lobata Extract and Pure Puerarin

TLDR
The pharmacokinetics of puerarin in Pueraria lobata may be dramatically different from pure puer Karin in the plasma of rat, and oral bioavailability of perarin may be increased when PLE was administrated to rats.

DEVELOPMENT AND IN VITRO EVALUATION OF PROTEIN LOADED PLGA MICROSPHERES

  • S. Basu
  • Materials Science, Chemistry
  • 2012
TLDR
A sustained release formulation of protein loaded PLGA microspheres containing bovine serum albumin (BSA) as a model drug and to evaluate the various physicochemical characteristics of the formulations, namelymicrospheres’ morphology, particle size, zeta potential, BSA encapsulation efficiency and in-vitro BSA release profile.

ASENAPINE MALEATE LOADED SOLID LIPID NANOPARTICLES FOR ORAL DELIVERY

Asenapine maleate (ASM) is a new second-generation antipsychotic approved in August 2009 by U.S FDA for the acute treatment of schizophrenia and manic or mixed episodes associated with bipolar

Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats

TLDR
Data suggests that PE-conjugated nanoliposomes released the drug in a sustained manner and were capable of distributing them in various organs and may be used for cell/ tissue targeting, attaching specific antibodies to PE.

Colon Targeted Protein Nanoparticles Loaded Suppositories : Effective against Intestinal Parasites

TLDR
The results of in vitro drug release testing proved that protein nanoparticle loaded suppositories is a better approach, compared to pure MZ loaded suppository, to achieve sustain release effect.

Phosphatidylethanolamine-conjugated nanoliposomes evaluation and characterization of doxorubicin-loaded liposomes and doxorubicin-loaded Pe liposomes Drug-excipients interaction study : Fourier transform infrared ( FTIR ) spectroscopy

TLDR
Data suggests that PE-conjugated nanoliposomes released the drug in a sustained manner and were capable of distributing them in various organs.

Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers

TLDR
The in-vitro protein release study suggests that release profile of BSA from nanoparticles could be modulated by changing protein-polymer ratios and/or by varying homogenizing speed during multiple-emulsion preparation technique.

Submicron-size biodegradable polymer-based didanosine particles for treating HIV at early stage: an in vitro study

TLDR
Experimental nanoparticles successfully transported didanosine to macrophages in vitro, suggesting reduction of dose, thus minimising toxicity and side effects, and developed nanoparticle may control HIV infection effectively at an early stage.