Preparation, characterization, and in vivo evaluation of insulin-loaded PLA-PEG microspheres for controlled parenteral drug delivery.

@article{Sheshala2009PreparationCA,
  title={Preparation, characterization, and in vivo evaluation of insulin-loaded PLA-PEG microspheres for controlled parenteral drug delivery.},
  author={Ravi Sheshala and Kok Khiang Peh and Yusrida Darwis},
  journal={Drug development and industrial pharmacy},
  year={2009},
  volume={35 11},
  pages={1364-74}
}
AIM The aim of this study was to prepare insulin-loaded poly(lactic acid)-polyethylene glycol microspheres that could control insulin release at least for 1 week and evaluate their in vivo performance in a streptozotocin-induced diabetic rat model. METHODS The microspheres were prepared using a water-in-oil-in-water double emulsion solvent evaporation technique. Different formulation variables influencing the yield, particle size, entrapment efficiency, and in vitro release profiles were… CONTINUE READING