Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins.

@article{Mellor2002PreparationBC,
  title={Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins.},
  author={Howard R Mellor and James K. Nolan and Lea Pickering and Mark R Wormald and Frances M Platt and Raymond A. Dwek and George W J Fleet and Terry D. Butters},
  journal={The Biochemical journal},
  year={2002},
  volume={366 Pt 1},
  pages={
          225-33
        }
}
We have reductively alkylated deoxynojirimycin imino sugars using sodium cyanoborohydride to provide an efficient means of generating a series of N-alkylated compounds containing 4-18 carbon side chains. The yields were greater than 90% using a variety of aldehydes of different chain lengths, and after purification were >95% pure using (1)H-NMR. Radiolabelled compounds were prepared using sodium cyanoborotriti-ide to selectively label the first carbon atom in the alkyl chain and used in protein… CONTINUE READING

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