Preparation, Characterization, in vivo Pharmacokinetics and Tumor Inhibition Properties of PEGylated Liposomes Containing Etoposide

@article{Jun2012PreparationCI,
  title={Preparation, Characterization, in vivo Pharmacokinetics and Tumor Inhibition Properties of PEGylated Liposomes Containing Etoposide},
  author={Shi Jun and Cheng Yi and Ma Fangli and Chen Weihong and Wang Xiaoyan},
  journal={2012 International Conference on Biomedical Engineering and Biotechnology},
  year={2012},
  pages={1614-1620}
}
Liposomal formulations of a potent antitumor drug, etoposide were prepared by ethanol injection method successfully. The characteristics of the etoposide liposomes, for particle size, encapsulation efficiency, leakage ratio, ξ potential and physical stability, were evaluated. In vivo pharmacokinetics and tumor inhibition ratio of mice were also examined. The liposomes were characterized by high entrapment efficiency, uniform size distribution and moderate ξ potential. In addition, the liposomes… CONTINUE READING