Preovulatory treatment of mice with anti-VEGF receptor 2 antibody inhibits angiogenesis in corpora lutea.

@article{Zimmermann2001PreovulatoryTO,
  title={Preovulatory treatment of mice with anti-VEGF receptor 2 antibody inhibits angiogenesis in corpora lutea.},
  author={Ralf Zimmermann and Tipton Hartman and Peter Bohlen and Mark V. Sauer and Jan Kitajewski},
  journal={Microvascular research},
  year={2001},
  volume={62 1},
  pages={15-25}
}
Adult mammalian angiogenesis occurs predominantly in female reproductive organs: the ovary and the uterus. Angiogenesis is very active during corpus luteum formation. A key regulator of angiogenesis is vascular endothelial growth factor (VEGF), which is highly expressed during corpus luteum formation. Inhibition of VEGF activity can block the formation and function of the corpora lutea by preventing angiogenesis. The VEGF receptor 2 (VEGF-R2) mediates the angiogenic action of VEGF and is… CONTINUE READING