Preoptic-hypothalamic periventricular lesions: thirst deficits and hypernatremia.

@article{Buggy1977PreoptichypothalamicPL,
  title={Preoptic-hypothalamic periventricular lesions: thirst deficits and hypernatremia.},
  author={James Buggy and A K Jonhson},
  journal={The American journal of physiology},
  year={1977},
  volume={233 1},
  pages={
          R44-52
        }
}
To assess the significance of stimulation studies suggesting an anteroventral third ventricle (AV3V) dipsogenic site of action for hyperosmotic and angiotensin thirst stimuli, electrolytic lesions of periventricular tissue surrounding AV3V were produced under ether anesthesia in rats preselected for responsiveness to subcutaneous angiotensin and hypertonic NaCl thirst challenges. Lesions limited to preoptic-anterior hypothalamic periventricular substrates resulted in adipsia; those rats… CONTINUE READING

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