Preoperative mucosal tolerance to brain antigens and a neuroprotective immune response following surgical brain injury.

@article{Ayer2012PreoperativeMT,
  title={Preoperative mucosal tolerance to brain antigens and a neuroprotective immune response following surgical brain injury.},
  author={Robert E. Ayer and Nazanin Jafarian and Wanqiu Chen and Richard L. Applegate and Austin R T Colohan and John H Zhang},
  journal={Journal of neurosurgery},
  year={2012},
  volume={116 1},
  pages={246-53}
}
OBJECT Intracranial surgery causes cortical injury from incisions, hemorrhage, retraction, and electrocautery. The term "surgical brain injury" (SBI) has been developed to categorize this injury inherent to the procedure. Neuroinflammation plays a significant role in SBI. Traditional antiinflammatory therapies are often limited by their immunosuppressive side effects and poor CNS penetration. This study uses mucosal tolerance to develop an immune system that is tolerant to brain myelin basic… CONTINUE READING

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