Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: the Lyon R0-04 phase II trial.

@article{Gerard2003PreoperativeCC,
  title={Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: the Lyon R0-04 phase II trial.},
  author={J. P. Gerard and Olivier Chapet and Chantal N{\'e}moz and Pascale Romestaing and Françoise Mornex and R{\'e}gis Coquard and Nicolas C. Barbet and Dan Atlan and Patrice Adeleine and Gilles Freyer},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2003},
  volume={21 6},
  pages={1119-24}
}
PURPOSE The combination of radiation, fluorouracil, and oxaliplatin in locally advanced rectal cancer has been shown to be feasible in a phase I trial. The purpose of this phase II trial was to assess tolerance and efficacy of this regimen in a preoperative setting. PATIENTS AND METHODS Between May 2000 and October 2001, 40 operable patients were entered onto the study. Radiotherapy was delivered with a three-field technique to a dose of 50 Gy over 5 weeks with a concomitant boost approach… CONTINUE READING

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