Preoperative concurrent chemoradiotherapy for stages II-IV oral squamous cell carcinoma: a retrospective analysis and the future possibility of this treatment strategy.

@article{Kirita2012PreoperativeCC,
  title={Preoperative concurrent chemoradiotherapy for stages II-IV oral squamous cell carcinoma: a retrospective analysis and the future possibility of this treatment strategy.},
  author={Tadaaki Kirita and Yuki Yamanaka and Yuichiro Imai and Nobuhiro Yamakawa and Kumiko Aoki and Yasuaki Nakagawa and Takahiro Yagyuu and Masakazu Hasegawa},
  journal={International journal of oral and maxillofacial surgery},
  year={2012},
  volume={41 4},
  pages={421-8}
}
This study evaluated survival in 154 patients with stages II-IV oral squamous cell carcinoma (OSCC) treated with preoperative concurrent chemoradiotherapy and assessed the future use of this treatment strategy. 14 patients exhibited advanced stage II, 73 exhibited stage III and 67 exhibited stage IV. All patients received 40Gy irradiation and concurrent cisplatin-based chemotherapy in two courses. Radical surgery was undertaken after 2-6 weeks. The clinical tumour response, histopathologic… CONTINUE READING