Preoperative chemoradiotherapy using concurrent capecitabine and irinotecan in magnetic resonance imaging-defined locally advanced rectal cancer: impact on long-term clinical outcomes.

@article{Gollins2011PreoperativeCU,
  title={Preoperative chemoradiotherapy using concurrent capecitabine and irinotecan in magnetic resonance imaging-defined locally advanced rectal cancer: impact on long-term clinical outcomes.},
  author={Simon William Gollins and Arthur Sun Myint and Brian J. Haylock and Marcus Wise and Mark P. Saunders and Rekha Neupane and Sharadah Essapen and Les Samuel and Mark Dougal and Arwel Lloyd and Jackie Morris and Clare Topham and Shabbir Susnerwala},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 8},
  pages={1042-9}
}
PURPOSE To assess long-term clinical outcomes of preoperative chemoradiotherapy of magnetic resonance imaging (MRI)-defined locally advanced rectal adenocarcinoma using concurrent irinotecan and capecitabine. PATIENTS AND METHODS One hundred ten patients without distant metastases entered this phase II trial North West/North Wales Clinical Oncology Group (NWCOG) -2 after MRI demonstration of tumor threatening (≤ 2 mm) or involving mesorectal fascia. Pelvic radiotherapy was given to 45 Gy in… CONTINUE READING

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