Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer.

@article{Kim2002PreoperativeCU,
  title={Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer.},
  author={Jun-Sang Kim and Jae-Sung Kim and M Cho and Kyu-Sang Song and W H Yoon},
  journal={International journal of radiation oncology, biology, physics},
  year={2002},
  volume={54 2},
  pages={403-8}
}
PURPOSE Capecitabine (Xeloda) is a new orally administered fluoropyrimidine carbamate that was rationally designed to exert its effect by tumor-selective activation. We attempted to evaluate the efficacy and toxicity of preoperative chemoradiation using capecitabine in locally advanced rectal cancer. METHODS AND MATERIALS Between July 1999 and March 2001, 45 patients with locally advanced rectal cancer (cT3/T4 or N+) were treated with preoperative chemoradiation. Radiation of 45 Gy/25… CONTINUE READING

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