Preoperative chemo(radio)therapy versus primary surgery for gastroesophageal adenocarcinoma: systematic review with meta-analysis combining individual patient and aggregate data.

@article{Ronellenfitsch2013PreoperativeCV,
  title={Preoperative chemo(radio)therapy versus primary surgery for gastroesophageal adenocarcinoma: systematic review with meta-analysis combining individual patient and aggregate data.},
  author={U Ronellenfitsch and Matthias Heinrich Martin Schwarzbach and Ralf-Dieter Hofheinz and Peter Kienle and Meinhard Kieser and Tracy E. Slanger and Bryan Burmeister and David K Kelsen and Donna Niedzwiecki and Christoph P Schuhmacher and Susan C Urba and Cornelis van de Velde and Thomas Noel Walsh and Marc Ychou and Katrin Jensen},
  journal={European journal of cancer},
  year={2013},
  volume={49 15},
  pages={3149-58}
}
BACKGROUND The prognosis of patients with gastroesophageal adenocarcinoma is poor. There is conflicting evidence regarding effects of preoperative chemotherapy on survival and other outcomes. METHODS We conducted a meta-analysis with aggregate and individual patient data (IPD) to assess the effect of preoperative chemotherapy for gastroesophageal adenocarcinoma on survival and other outcomes. Two independent reviewers identified eligible randomised controlled trials (RCTs) comparing… CONTINUE READING