Preoperative capecitabine and pelvic radiation in locally advanced rectal cancer--is it equivalent to 5-FU infusion plus leucovorin and radiotherapy?

@article{Chan2010PreoperativeCA,
  title={Preoperative capecitabine and pelvic radiation in locally advanced rectal cancer--is it equivalent to 5-FU infusion plus leucovorin and radiotherapy?},
  author={Alexander K P Chan and Alfred O Wong and Daryl A Jenken},
  journal={International journal of radiation oncology, biology, physics},
  year={2010},
  volume={76 5},
  pages={
          1413-9
        }
}
PURPOSE The aim of this retrospective case-matching study was to compare the treatment outcomes and acute toxicity of preoperative radiotherapy (RT) with capecitabine vs. preoperative RT with intermittent 5-fluorouracil (5-FU) infusion, leucovorin, and mitomycin C in rectal cancer. METHODS AND MATERIALS We matched 34 patients who were treated with preoperative concurrent capecitabine and 50 Gy of RT by their clinical T stage (T3 or T4) and the tumor location (<or=7 cm or >7 cm from the anal… CONTINUE READING
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