Preoperative FLAC/Granulocyte-Colony-Stimulating Factor Chemotherapy for Stage II Breast Cancer: A Prospective Randomized Trial

@article{Danforth2003PreoperativeFF,
  title={Preoperative FLAC/Granulocyte-Colony-Stimulating Factor Chemotherapy for Stage II Breast Cancer: A Prospective Randomized Trial},
  author={David N. Danforth and MD Kenneth Cowan and Rosemary M Altemus and Mar{\'i}a Merino and Catherine Chow and RN ArleneBerman and Usha Chaudhry and Craig Shriver and Seth Steinberg and Jo Anne Zujewski},
  journal={Annals of Surgical Oncology},
  year={2003},
  volume={10},
  pages={635-644}
}
Background: Preoperative chemotherapy for stage II breast cancer may reduce locoregional tumors and provides initial treatment for systemic micrometastases. We conducted a prospective, randomized trial to evaluate the ability of intensive preoperative chemotherapy to enhance the outcome of this approach. Methods: Patients with clinical stage II breast cancer (T2N0, T1N1, and T2N1) were prospectively randomized to receive either preoperative or postoperative chemotherapy with five 21-day cycles… CONTINUE READING
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