Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation.

Abstract

Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active.

DOI: 10.1016/j.ejmech.2010.06.025

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Cite this paper

@article{Basabe2010PrenylflavonoidsAP, title={Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation.}, author={Pilar Basabe and M{\'o}nica de Rom{\'a}n and Isidro S. Marcos and David D{\'i}ez and Almudena Blanco and Olga Bodero and Faustino Mollinedo and Beatriz G Sierra and Julio G Urones}, journal={European journal of medicinal chemistry}, year={2010}, volume={45 9}, pages={4258-69} }