Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol

@article{Fellermeier1998PrenylationOO,
  title={Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol},
  author={M. Fellermeier and M. Zenk},
  journal={FEBS Letters},
  year={1998},
  volume={427}
}
  • M. Fellermeier, M. Zenk
  • Published 1998
  • Chemistry, Medicine
  • FEBS Letters
  • A new enzyme, geranylpyrophosphate:olivetolate geranyltransferase (GOT), the first enzyme in the biosynthesis of cannabinoids could be detected in extracts of young leaves of Cannabis sativa. The enzyme accepts geranylpyrophosphate (GPP) and to a lesser degree also nerylpyrophosphate (NPP) as a cosubstrate. It is, however, specific for olivetolic acid; its decarboxylation product olivetol is inactive as a prenyl acceptor. 
    131 Citations
    Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway
    • 73
    • PDF
    Biosynthesis of cannabinoids
    • 116
    Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides
    • 135
    • Highly Influenced
    • PDF
    Molecules of InterestHyperforin
    • 90
    Prenyl transfer to aromatic substrates: genetics and enzymology.
    • L. Heide
    • Biology, Medicine
    • Current opinion in chemical biology
    • 2009
    • 136
    • PDF
    The first prenylation step in hyperforin biosynthesis.
    • 39

    References

    SHOWING 1-10 OF 17 REFERENCES
    Purification and Characterization of Cannabidiolic-acid Synthase from Cannabis sativa L.
    • 93
    • PDF