• DOI:10.1016/S0014-5793(98)00450-5
Corpus ID: 7777284

Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol

@article{Fellermeier1998PrenylationOO,
  title={Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol},
  author={M. Fellermeier and M. Zenk},
  journal={FEBS Letters},
  year={1998},
  volume={427}
}

M. Fellermeier, M. Zenk

Published 1998

Chemistry, Medicine

FEBS Letters

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A new enzyme, geranylpyrophosphate:olivetolate geranyltransferase (GOT), the first enzyme in the biosynthesis of cannabinoids could be detected in extracts of young leaves of Cannabis sativa. The enzyme accepts geranylpyrophosphate (GPP) and to a lesser degree also nerylpyrophosphate (NPP) as a cosubstrate. It is, however, specific for olivetolic acid; its decarboxylation product olivetol is inactive as a prenyl acceptor.