Prenylation and Backbone Structure of Flavonoids and Isoflavonoids from Licorice and Hop Influence Their Phase I and II Metabolism.

@article{Schans2015PrenylationAB,
  title={Prenylation and Backbone Structure of Flavonoids and Isoflavonoids from Licorice and Hop Influence Their Phase I and II Metabolism.},
  author={Milou G. M. van de Schans and Toine F H Bovee and Geert M. Stoopen and Marlies Lorist and Harry Gruppen and Jean-Paul Vincken},
  journal={Journal of agricultural and food chemistry},
  year={2015},
  volume={63 49},
  pages={
          10628-40
        }
}
In vitro liver metabolism of 11 prenylated flavonoids and isoflavonoids was investigated by determining their phase I glucuronyl and sulfate metabolites using pork liver preparations. One hundred metabolites were annotated using RP-UHPLC-ESI-MS(n). A mass spectrometry-based data interpretation guideline was proposed for the tentative annotation of the position of hydroxyl groups, considering its relevance for estrogenic activity. To relate structure to metabolism, compounds were classified on… CONTINUE READING
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