Prenylated xanthones: antiproliferative effects and enhancement of the growth inhibitory action of 4-hydroxytamoxifen in estrogen receptor-positive breast cancer cell line

@article{Paiva2011PrenylatedXA,
  title={Prenylated xanthones: antiproliferative effects and enhancement of the growth inhibitory action of 4-hydroxytamoxifen in estrogen receptor-positive breast cancer cell line},
  author={Ana Mafalda Paiva and M. Em{\'i}lia Sousa and Ana Cam{\~o}es and Maria de S{\~a}o Jos{\'e} Nascimento and Madalena Maria de Magalh{\~a}es Pinto},
  journal={Medicinal Chemistry Research},
  year={2011},
  volume={21},
  pages={552-558}
}
The effects of three prenylated xanthones on the in vitro growth of estrogen-dependent ER (+) MCF-7 (breast), estrogen-independent ER (−) MDA-MB-231 cells (breast), and NCI-H460 (non-small cell lung) were investigated in a complete and/or steroid-free medium. 3,4-Dihydro-12-hydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one (4), the most potent against the ER(+) MCF-7 cell line (GI50 = 5 μM), showed an enhancement in the anti-estrogenic effect of 4-hydroxytamoxifen in this ER(+) cell line. 

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