Prenylamine block of Nav1.5 channel is mediated via a receptor distinct from that of local anesthetics.

@article{Mujtaba2002PrenylamineBO,
  title={Prenylamine block of Nav1.5 channel is mediated via a receptor distinct from that of local anesthetics.},
  author={M. Mujtaba and Sho-Ya Wang and G. Wang},
  journal={Molecular pharmacology},
  year={2002},
  volume={62 2},
  pages={
          415-22
        }
}
We have shown previously that prenylamine, a calcium channel blocker, has potent local anesthetic activity in vivo and in vitro. We now characterize the tonic and use-dependent block of prenylamine on wild-type human cardiac voltage-gated sodium channels (hNav1.5) transiently expressed in human embryonic kidney 293t cells under whole-cell voltage-clamp condition. We also determine whether prenylamine and local anesthetics interact with a common binding site on the Nav1.5 channel by analyzing… Expand
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