Prenatal therapy in transient abnormal myelopoiesis: a systematic review

@article{Tamblyn2015PrenatalTI,
  title={Prenatal therapy in transient abnormal myelopoiesis: a systematic review},
  author={Jennifer Tamblyn and Alice Norton and Laura Spurgeon and V. Donovan and A R Bedford Russell and Joanna Bonnici and Kelly J. Perkins and Paresh Vyas and Irene Roberts and Mark David Kilby},
  journal={Archives of Disease in Childhood: Fetal and Neonatal Edition},
  year={2015},
  volume={101},
  pages={67 - 71}
}
Objective To systematically review current evidence regarding prenatal diagnosis and management of transient abnormal myelopoiesis (TAM) in fetuses with trisomy 21. A novel case of GATA1-positive TAM, in which following serial in utero blood transfusion clinical improvement and postnatal remission were observed, is included. Search strategy and data collection A systematic search of electronic databases (inception to October 2014) and reference lists, hand-searching of journals and expert… 
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The prenatal diagnosis of a transient myeloproliferative disorder suggestive of leukaemia in a fetus with hepatosplenomegaly, hydrops and 47, XY,+21 karyotype and post‐mortem examination revealed marked liver and splenic necrosis without evidence of residual leukaemic infiltration in any organ.
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‘Transient abnormal myelopoiesis’ (TAM), a condition associated with Down syndrome, was considered in the differential diagnosis of a 30-year-old multipara referred after the results of a fetal anomaly scan showed a nuchal measurement of 6.2 mm.
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TLDR
Transient myeloproliferative disorder has been seen in neonates with trisomy 21 and may be a cause of hydrops in some aneuploid fetuses, and Chromosomal analysis should not be excluded in the workup of nonimmune hydrops when anemia is found, and therapy is withheld until karyotyping has been performed.
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TLDR
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TLDR
Three cases of transient abnormal myelopoiesis associated with trisomy 21 in which hepatomegaly was apparent during the fetal period are presented, raising the question of whether fetal hepatosplenomegally is a predictor of transient myeliproliferative disorder with tr isomy 21 and whether the degree of fetal hepatomeGaly is a marker for the neonatal severity of hematological abnormalities.
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TLDR
A case of TAM with hepatosplenomegaly found on ultrasound and associated with an increased amniotic fluid Δ OD 450 value is reported, suggesting that amniocentesis with chromosomal analysis and a ΔOD 450 may aid in diagnosing TAM and predicting the severity of the liver involvement.
Prenatal Diagnosis of Transient Abnormal Myelopoiesis in a Down Syndrome Fetus
We report a case of transient abnormal myelopoiesis in a Down syndrome fetus diagnosed at 28+3 weeks of gestation that rapidly progressed to intrauterine death 10 days later. Fetal hepatosplenomegaly
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