Prenatal therapy in transient abnormal myelopoiesis: a systematic review

@article{Tamblyn2015PrenatalTI,
  title={Prenatal therapy in transient abnormal myelopoiesis: a systematic review},
  author={Jennifer Tamblyn and Alice Norton and Laura Spurgeon and V. Donovan and A R Bedford Russell and Joanna Bonnici and Kelly J. Perkins and Paresh Vyas and Irene Roberts and Mark David Kilby},
  journal={Archives of Disease in Childhood: Fetal and Neonatal Edition},
  year={2015},
  volume={101},
  pages={67 - 71}
}
Objective To systematically review current evidence regarding prenatal diagnosis and management of transient abnormal myelopoiesis (TAM) in fetuses with trisomy 21. A novel case of GATA1-positive TAM, in which following serial in utero blood transfusion clinical improvement and postnatal remission were observed, is included. Search strategy and data collection A systematic search of electronic databases (inception to October 2014) and reference lists, hand-searching of journals and expert… 
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21 Citations
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21 Citations

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Transient Myeloproliferative Disorder in Neonates with Down syndrome: Case Report and Review
TLDR
This is the report of a preterm newborn with Down syndrome diagnosed with TMD that required chemotherapy on the first days of life due to a poor clinical course and other risk factors for early death.
Perinatal Transient Myeloproliferative Disorder in Trisomy 21
Transient myeloproliferative disorder (TMD), also known as transient acute myelopoiesis, is a myeloproliferative condition that occurs in the perinatal period in up to 10% of patients who have Down…
Actual gynecology and obstetrics Transient myeloproliferative syndrome in newborn without Down syndrome phenotype : a unique case report
We report a unique case of a rare prenatal diagnosis of transient myeloproliferative disorder mimicking congenital leukemia, since child had no features associated with Down syndrome. Leukemic…
Recent advances in the understanding of transient abnormal myelopoiesis in Down syndrome
  • Kenichiro Watanabe
  • Medicine
    Pediatrics international : official journal of the Japan Pediatric Society
  • 2019
TLDR
Investigation of TAM, a unique pre‐leukemic condition, will continue to strongly influence basic and clinical research into the development of hematological malignancies.
TRANSIENT ABNORMAL MYELOPOIESIS AT BIRTH IN AN INFANT WITH DOWN SYNDROME: A UNIQUE ENTITY
Transient abnormal myelopoiesis (TAM) is a hematological disorder, which is rare but unique for children with Down syndrome. It is important to diagnose this entity, as these children are at 500…
Transient myeloproliferative syndrome in newborn without Down syndrome phenotype: a unique case report
TLDR
Based on an early prenatal suspicion and quick and intensive postnatal intervention patient survived, a unique case of a rare prenatal diagnosis of transient myeloproliferative disorder mimicking congenital leukemia, since child had no features associated with Down syndrome.
Prenatal diagnosis of transient abnormal myelopoiesis in three fetuses with Down syndrome: heterogeneous ultrasonographic findings and outcomes
TLDR
Three cases of TAM characterized by heterogeneous ultrasonographic findings and outcomes are described, including a 27-year-old woman with severe fetal hepatosplenomegaly.
Fetal hydrops – a review and a clinical approach to identifying the cause
TLDR
This review focusses on nonimmune fetal hydrops and discusses in detail the most common etiologies such as infection and chromosomal abnormalities and cover rarer presentations of congenital malformation and single-gene disorders.
Transient Myeloproliferative Disorder: An Update for Neonatal Nurses
Down syndrome (DS) is a well-known genetic disorder that affects 700–1,000 infants per year. One particular comorbidity of DS is transient myeloproliferative disorder (TMD), a disease characterized…
Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update
Children with constitutional trisomy 21 (Down syndrome (DS)) have a unique predisposition to develop myeloid leukaemia of Down syndrome (ML-DS). This disorder is preceded by a transient neonatal…
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References

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TLDR
The prenatal diagnosis of a transient myeloproliferative disorder suggestive of leukaemia in a fetus with hepatosplenomegaly, hydrops and 47, XY,+21 karyotype and post‐mortem examination revealed marked liver and splenic necrosis without evidence of residual leukaemic infiltration in any organ.
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TLDR
‘Transient abnormal myelopoiesis’ (TAM), a condition associated with Down syndrome, was considered in the differential diagnosis of a 30-year-old multipara referred after the results of a fetal anomaly scan showed a nuchal measurement of 6.2 mm.
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TLDR
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TLDR
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TLDR
Transient myeloproliferative disorder has been seen in neonates with trisomy 21 and may be a cause of hydrops in some aneuploid fetuses, and Chromosomal analysis should not be excluded in the workup of nonimmune hydrops when anemia is found, and therapy is withheld until karyotyping has been performed.
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TLDR
A case of transient abnormal myelopoiesis (TAM) presenting as non-immune fetal hydrops with NIHF detected at 29 weeks’ gestation is presented and the subsequent diagnosis and management of in utero TAM is discussed.
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TLDR
The subject patient with Down's syndrome developed isolated pericardial effusion, transient abnormal myelopoiesis (TAM), and hypothyroidism, which disappeared after treatment with prednisolone at a dose of 2 mg/kg/day.
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TLDR
Three cases of transient abnormal myelopoiesis associated with trisomy 21 in which hepatomegaly was apparent during the fetal period are presented, raising the question of whether fetal hepatosplenomegally is a predictor of transient myeliproliferative disorder with tr isomy 21 and whether the degree of fetal hepatomeGaly is a marker for the neonatal severity of hematological abnormalities.
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TLDR
A case of TAM with hepatosplenomegaly found on ultrasound and associated with an increased amniotic fluid Δ OD 450 value is reported, suggesting that amniocentesis with chromosomal analysis and a ΔOD 450 may aid in diagnosing TAM and predicting the severity of the liver involvement.
Prenatal Diagnosis of Transient Abnormal Myelopoiesis in a Down Syndrome Fetus
We report a case of transient abnormal myelopoiesis in a Down syndrome fetus diagnosed at 28+3 weeks of gestation that rapidly progressed to intrauterine death 10 days later. Fetal hepatosplenomegaly…
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