Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat

  title={Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat},
  author={Marta Weinstock and E. A. Matlina and G. Maor and Haim Rosen and Bruce S. McEwen},
  journal={Brain Research},

Prenatal stress alters Fos protein expression in hippocampus and locus coeruleus stress-related brain structures

Hypothalamo-Pituitary-Adrenocortical Axis Function and Hedonic Behavior in Adult Male and Female Rats Prenatally Stressed by Maternal Food Restriction

The present experiments failed to reveal a decrease in hedonic behavior in prenatally stressed rats, and observed changes in hormone and CRH mRNA levels indicate that the gestational stress used did not result in a depression-like state in adult offspring.

Mild Prenatal Stress Causes Emotional and Brain Structural Modifications in Rats of Both Sexes

It is shown that stressful events during pregnancy can lead to long-lasting structural and neurochemical effects in the offspring, which affect behavior in adulthood.

Differential adaptive responses to chronic stress of maternally stressed male mice offspring.

Exposure to maternal stress in the womb can affect an animal's coping capacity to chronic postnatal stress, and it was demonstrated that a dysfunction in negative feedback inhibition of the HPA axis could be deteriorated by chronic stress in maternally stressed male mice.

Prenatal stress alters circadian activity of hypothalamo-pituitary-adrenal axis and hippocampal corticosteroid receptors in adult rats of both gender.

Results show that prenatally stressed rats exhibit an altered temporal functioning of the HPA axis, which reinforces the idea of a general homeostatic dysfunction in those animals, and could be mediated by a reduction in corticosteroid receptors at specific times of day.

Sexually dimorphic effects of prenatal stress on cognition, hormonal responses, and central neurotransmitters.

Data reinforce the view that prenatal stress affects multiple aspects of brain development, interfering with the expression of normal behavioral, neuroendocrine, and neurochemical sex differences, and implications for the effects of prenatal stress on the development of sexually dimorphic endocrine and neurological disorders.



Prenatal stress: Effects on brain biogenic amine and plasma corticosterone levels

  • D. Peters
  • Biology, Psychology
    Pharmacology Biochemistry and Behavior
  • 1982

Hyperresponsiveness to stress: differential effects of prenatal ethanol on males and females.

  • J. Weinberg
  • Psychology, Biology
    Alcoholism, clinical and experimental research
  • 1988
In this study, the hypothesis that pituitary-adrenal response inhibition is compromised in animals prenatally exposed to ethanol is investigated and adrenocortical habituation to a stressful stimulus is examined.

Persistent alteration of pituitary-adrenal function in the rat by prepuberal corticosterone treatment.

Two distinct periods exist in the postnatal development of the rat during which basal and diurnal pituitary-adrenal activity can be differentially and persistently altered by treatment with the naturally occurring glucocorticoid.

Effects of stress administered during pregnancy on reproductive capacity and subsequent development of the offspring of rats: prolonged effects on the litters of a second pregnancy.

  • I. Pollard
  • Psychology, Biology
    The Journal of endocrinology
  • 1984
The offspring of both sexes from stressed mothers responded differently from the controls when subjected to short-term stress (one session) in adulthood, and their increase in plasma corticosterone concentration was significantly below that of the controls.

Effects of Prenatal Maternal Handling and Differential Housing on Offspring Emotionality, Plasma Corticosterone Levels, and Susceptibility to Gastric Erosions

An interaction between prenatal treatment and housing was observed, the difference between prenatally handled and control animals being most pronounced among the individually housed populations.