Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat.

@article{Weinstock1992PrenatalSS,
  title={Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat.},
  author={Marta Weinstock and E Sh Matlina and Gila Maor and Haim Rosen and Bruce S. McEwen},
  journal={Brain research},
  year={1992},
  volume={595 2},
  pages={195-200}
}
A study was made of the effects of prenatal stress on the reactivity of the hypothalamic-pituitary adrenal (HPA) axis in male and female offspring. Rat dams were subjected to noise and light stress on an unpredictable basis throughout pregnancy. At 28 days of age mRNA for POMC, proenkephalin and prodynorphin were measured in the hypothalamus of the offspring. A marked reduction was found in POMC mRNA in PS females (PSF) but not in males (PSM), but the other mRNA's did not differ from controls… CONTINUE READING
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